About our group
How membrane binding proteins assemble into large multi protein complexes that subsequently modify the membrane chemically or physically is key question of our laboratory. Hijacking of host proteins (especially membrane modifying enzymes) by viruses is another question that our laboratory aims to answer. We use mainly protein crystallography and other biophysical methods to understand the structure and function of membrane binding/modifying proteins in detail and structure aided medicinal chemistry to develop inhibitors of viral replication.
(Picture legend: Left: Multi-protein assembly of the lipid kinase PI4KB. Pseudo-atomic model based on structural data. Right: A virus is using human ACBD3 protein to hijack cellular machinery into building its replication factories. Bottom: Human and viral protein cooperate to “make” a new virus.)